SYNTHESIS OF CARDIOTONIC IMIDAZOPYRIDINE
- VernacularTitle:强心咪啶的合成
- Author:
Changsheng SUN
- Publication Type:Journal Article
- Keywords:
cadiotonic agent imidazo [4, 5-b] pyridine
- From:
Academic Journal of Second Military Medical University
1981;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
A new orally active non-glycosidic, non-adrenergic cardiotonic agent, 2-[(2-me-thoxy-4-methysulfinyl) phenyl]-1 H-imidazo[4, 5-b]-pyridine, AR-L115BS, has been synthesized.The two key intermediates, 2, 3-diaminopyridine and 2-methoxy-4-methylmercap-tobenzoic acid were prepared according to the routes submitted by Fox and Zipp, respectively. The approaches were improved to adapt large scale laboratory preparation. The structure of the end product was proved by elemental analysis,mass spectra, 1H nuclear magnetic resonance spectra and infrared spectra.
