THE ACTIVITY OF ERYTHROCYTE MEMBRANE Na~+ -K~+ ATPase IN PATIENTS OF ESSENTIAL HYPERTENSION TREATED AND UNTREATED WITH LIGUSTICUM WALLICHII HORT
- VernacularTitle:人红细胞膜Na~+-K~+-ATP酶的研究Ⅱ原发性高血压病人红细胞膜Na~+-K~+-TP酶活力及川芎治疗后酶活力变化的观察
- Author:
Yaomei WEI
- Publication Type:Journal Article
- Keywords:
cell membrane Na+-K+ATPase hypertension Ligusticum Wallichii Hort
- From:
Academic Journal of Second Military Medical University
1981;0(04):-
- CountryChina
- Language:Chinese
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Abstract:
The activity of erythrocyte membrane Na+-K+ATPase was determined from 43 patients with essential hypertension and 10 normotensive controls. Erythrocyte membrane preparation was obtained by washing after hypotonic hemolysis and repeating high speed centrifugal sedimentation. Ouabain was used as a specific inhibitor in Na+-K+ATPase assay. A significantly decreased activity of erythrocyte membrane Na+-K+ATPase was found in these patients of hypertension. Although their clinical manifestations were improved, there were no differences in Na + -K+ATPase activity between treated with Ligusticum Wallichii Hort and untreated groups. The mechanisms involved in these changes were discussed.
