The Effect of Combined Radiation-Burn Injury on Intestinal Epithelium in Mice
- VernacularTitle:小鼠肠型放射损伤合并烧伤对小肠上皮细胞的复合效应
- Author:
Yongpin SU
;
Tianmin CHEN
- Publication Type:Journal Article
- Keywords:
Combined effect;
Irradiation;
Combined radiation-burn injuries;
Irradiation disease of intestinal typej Injury of intestinal epithelial cells;
Burn
- From:Journal of Third Military Medical University
1983;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Seven hundred and forty-six mice, weighing 30-35 grams, were divided into four groups randomly. The animals of the first three groups were inflicted with radiation injury (12 Gy total body irradiation from a Co60 source) , burn injury (15% of third degree burns), and combined injury of radiation and burns(12 Gy total body irradiation and 15% of third degree burns) respectively. The fourth group worked as normal control.The mortality and the dynamic changes of the intestinal epithelium of the experimental animals were studied. It was found that the clinical course of the combined injury group was quite different from other two. The mortality of the combined injury group was higher and the damage on the intestinal epithelium was more severe than those of the radiation injury group in the first 48 hours after injury. In the second 48 hours, the mortality of the combined injury group became lower and the recovery of the intestinal epithelium faster.The reactions of the experimental animals to the combined injury of radiation and burn were-very complicate. Further investigation is essential to elucidate the mechanism and to formulate appropriate therapeutic measures.
