Changes of Skeletal Muscle Cellular Membrane Potential during Hemorrhagic Shock & Its Relationship to Cellular Function Disturbance
- VernacularTitle:骨骼肌细胞膜电位在失血性休克时的变化及其与细胞功能障碍的关系
- Author:
Jianghuai WANG
;
Xichang LU
;
Guanghai LIE
;
Chengying WANG
;
Songmin LU
;
Suqing GUO
;
Ganquan HOU
- Publication Type:Journal Article
- Keywords:
Rabbit;
Hemorrhagic Shock;
Microelectrode;
Cellular Membrane Potential;
Electrolytes and Water Distribution;
Cellular Membrane Function
- From:Journal of Third Military Medical University
1983;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
This paper is to report the determination of the skeletal muscle cellular membrane potential (SMCMP) in vivo with the technique of "Semi-floating"glass microelectrode. The changes of SMCMP and the distribution of extra- and intracellular electrolytes and water in different phases of irreversible hemo-rrhagic shock in rabbits were studied systematically.It was found that SMCMP decreased significantly and immediately as soon as hypotension occurred, which means that the functions of the cellular membrane begin to deteriorate in the early stage of shock; SMCMP continued to decrease when the shock was progressing, which reflects that besides the failure of the cellular membrane function, there is also the degradation of the functions of the cell proper; the leakage of the intracellular potassium across the cellular membrane and the retention of the intracellular sodium and water occurred three hours after the onset of the shock, which indicates that the inability of cells to regulate their volume.
