The Clinical Significance of Anti-LSP Antibodies in the Sera of Patients with Viral Hepatitis: An Evaluation with SPA-RIA & ELISA
- VernacularTitle:病毒性肝炎患者抗-LSP抗体的临床意义——SPA-RIA和ELISA检测结果的评价
- Author:
Mengdong LI
;
Changqing HE
;
Zhiyong ZHENG
;
Maoping CHENG
- Publication Type:Journal Article
- Keywords:
Liver specific membrane lipopcotein (LSP);
Staphylococcal protein A radioimmunoprecipitation assay (SPA-RIA);
Enzyme linked immuno-sorbent assay (ELISA)s Ckronic active hepatitis (CAH);
Ghronic persistent hepatitis (CPH)
- From:Journal of Third Military Medical University
1983;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Antibodies against LSP in the sera of 168 patients with various types of viral hepatitis were determined with SPA-RIA. The sera of another group of 178 patients (109 of them were from the first group) with viral hepatitis were studied with ELISA for the same antibodies, which were further divided into three categories, that is, IgG, IgM and IgA classes. The results of 109 patients examined with both of the two methods, indicated that anti-LSP antibodies measured by SPA-RIA might mainly represent anti-LSP IgG class. It was found that circu-lating anti-LSP antibodies could easily be detected in most patients with either acute or chronic hepatitis. After analyzing the-results, the authors suggest that the humoral immune response against LSP might not be the sole initiating factor in the pathogenesis of viral hepatitis, they are more likely the result of the antigen variation of the injured liver cells.
