STUDIES ON RADIATION EFFECTS OF NEUTRON AND ?-RAY TO THE DRUGS
- VernacularTitle:中子及?线辐射对药物的影响
- Author:
Keming CHEN
- Publication Type:Journal Article
- Keywords:
neutrons gamma rays radiation drugs (drugs storage)
- From:
Academic Journal of Second Military Medical University
1982;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Seventy two kinds of drugs were irradiated by neutron (1?1013cm-2) and ?-ray (1?104R) to evalute their radioactivity, potency, content and some other physicohe-mical properties at intervals of 48 hrs and 3 months after exposure. LD50 of 36 kinds of drugs were measured and main pharmacological effect of 40 kinds of drugs were observed .The induced radioactivities of drugs, the 5% glucose in normal saline and the injection KC1 were found to be about 1? 10-1 ?Ci/ml, the rest were either about equal to or less than 1?10-2 ?Ci/ml(g.).No radiative effdcts were observed among these drugs with the exception of VitB12, ether and 0.1% citric acid The content of VitB12 was dropped after the radiation. Its decrease was found to be proportional to the dose of radiation.Slight changes in color and content were found in 10 of these drugs after radiation, but their extents were within the normal ranges according to the Chinese Pharmacopoeia.
