THE EFFECTS OF CHRONIC ADMINISTRATION OF HYDROCORT- ISONE ON THE GLUCOCORTICOID RECEPTOR OF HEPATIC CYTSOL IN RATS
- VernacularTitle:慢性给予糖皮质激素对大鼠肝胞液糖皮质激素受体的影响
- Author:
Renbau XU
- Publication Type:Journal Article
- Keywords:
hydrocertisenc receptors, drugs (glucocorticoid receptors) cytosol (hepatic cytosol)
- From:
Academic Journal of Second Military Medical University
1982;0(02):-
- CountryChina
- Language:Chinese
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Abstract:
The daily intramuscular injections of hydrocortisone acetate for about 20 days (2 mg/100g body weight per day), resulted in a marked decrease of specific binding capacity (Ro) and an increase of the equilibrium dissociation constant (Kd) of the hepatic cytosol with [3H] dexamethasone in rats. There were no changes of Ro and Kd in the control groups after saline injection for about 20 days or a single injection of hydro-cortisone acetate 5 hours or 24 hours prior to sacrification of the animals. The results indicated the exsistence of down-regulation of glucocorticoid hormone to its homologous receptor after chronic admnistration of glucocrticoid hormone.
