RADIATION DAMAGE AND RECOVERY OF HEMOPOIETIC STEM CELLS IV. THE EFFECT OF BENZOATE ESTRADIOL ON DAMAGE AND RECOVERY OF HEMOPOIETIC STEM CELLS IN IRRADIATED MICE
- VernacularTitle:造血干细胞辐射损伤和修复的研究Ⅳ.——苯甲酸雌二醇对小鼠造血干细胞辐射损伤和修复的影响
- Author:
Minghua ZHANG
- Publication Type:Journal Article
- Keywords:
haemopoietic stem cells benzoate estradiol CFU-D CFU-S chromosomal aberrations mitotic index gamma irradiation
- From:
Academic Journal of Second Military Medical University
1982;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
The effect of benzoate estradiol on hemopoiesis in irradiated mice was studied withassays of granulocyto-macrophage progenitic cells (CFU-D) and endogenous spleencolonies (CFU-S) in bone marrow and simultaneous determinations of mitotic index andfrequency of chromosomal aberrations of bone marrow cells, after a single intramuscularinjection of benzoate estradiol 7 days before irradiation.in the initial stage postirradiation, no significant difference was found between thr mean values neither the number of CFU-D nor the frequncy of chromosomal aberrations of both groups , whereas on the 3th, 5th and 9th day, the production of CFU-D of the pretrated group was increased markedly than that of non-treated control group. In addition, a significant increase in the mitotic index of bone marrow cells was observed by days 3-5 postirradiation in pretreated group.These observations suggest that benzoate estradiol provoke an enhancement of prol -eferation of residual stem cell , srather than a decrease its radiosensetivity.
