Creation of chelated complex of hydro propyl - beta - cyclodextrin (HPLC) with dehydroepiadrosteron by spray - dry method
- Author:
Tu Minh Koong
- Publication Type:Journal Article
- Keywords:
Creation of chelated complex*spray - dry method
- MeSH:
Chromatography, High Pressure Liquid;
pharmacy;
chemistry
- From:Pharmaceutical Journal
2003;323(3):15-17
- CountryViet Nam
- Language:Vietnamese
-
Abstract:
Quantify dehydrooepiandrosteron (DHEA) by HPLC to define melt degree of DHEA in HPCD solution and make up cheated complex of HPCD by spray-dry method. Result shows: HPCD increases clearly melt degree of DHEA in water. In survey interval following the method, melt degree of DHEA linear increase compare HPCN level in solution. The complexes of about 11% DHEA calculated on dried substance dissolved easily in water. The X-ray dif-fraction spectrum of the complexes was formless agent and different clearly compared the physical mixture spectrum HPCD/DHEA.
