Effect of Decreased plasma Colloid Osmotic pressure on Lung Water Content in Rats under simulated High Altitude
- VernacularTitle:模拟高原低氧时降低血浆蛋白渗透压对大白鼠肺含水量的影响
- Author:
Shiqun LIU
;
Jingsheng GAO
;
Deqin LI
;
Zhen PEI
;
Li MA
- Publication Type:Journal Article
- From:Journal of Third Military Medical University
1983;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Rats were made to bleed and about 40% of the total blood volume was lost. A replacement of Ringer's solution of the volume four times the lost blood volume was given and the animals were closely monitored for 24 hours. The hemoglobin level of the animals was low throughout the course of observation. The plasma colloid osmotic pressure reached the lowest point 15 minutes after bleeding, and then gradually rising up returned to a level about 90% of the control value at the end of 24 hours. The relativity between the plasma colloid osmotic pressure and the lung water content was quite significant in those rats in a low altitude environment (P0.05).The result indicates that the increased lung water content due to decreased plasma osmotic pressure could not be made further worse by hypoxia due to high altitude. The characteristic pulmonary hemodynamic changSs caused by hypoxia might be considered as the explanation of the phenomenon.
