EFFECTS OF SOME DRUGS ON THE TURNOVER OF NICOTINIC ACETYLCHOLINE RECEPTOR
- VernacularTitle:某些药物对N-胆碱受体代谢的影响
- Author:
Qingwu MAO
- Publication Type:Journal Article
- From:
Academic Journal of Second Military Medical University
1982;0(02):-
- CountryChina
- Language:Chinese
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Abstract:
The present study describes the effects of carbamate anti-cholinesterase agents and other drugs on the binding sites and on the turnover of nicotinic acetylcholine receptors (N-AChR). The direct binding studies with 125I-?-Bungarotoxin have shown that the neostigmine, prostigmine, pyridostigmine, and ambenonium specifically blockada the N-AChR binding sites, but physostigmine has no directly effect on the N-AChR binding sites.Small dose of ambenomine increases degradation rate of surface N-AChR and it decreases the rate of new N-AChR incorporation into membrane. The bindings of sodium phenobabital to N-AChR sites are very similar to those of d-tubocurarine. The parathion(E605)has no direct bindes to N-AChR sites. The density of extrajunc-tional N-AChR sites is increased and the RBI is 1.46.
