SYNTHESIS OF AN ORAL ANTIFUNGAL KETOCONAZOLE
- VernacularTitle:口服抗真菌药—酮康唑的合成
- Author:
Jiqiu YANG
- Publication Type:Journal Article
- From:
Academic Journal of Second Military Medical University
1982;0(01):-
- CountryChina
- Language:Chinese
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Abstract:
Ketoconazle is a new effective broad-spectrum antifugal agent with least toxicity. It is used as an oral antifungal agent and has been shown to produce therapeutic responses in systemic and superficial fungal infections.Ketcconazole was synthesized according to the method reported by Heeres et al, with improvement in process.In this paper a rout for the synthesis of the intermediate 1-acetyl -4-(4-hydroxylphenyl) piperazine(XI)was also presented. The synthetic product and the intermediate were proved by elemental analysis.
