STUDIES ON PHOTOSENSITIZING AGENTS OF TUMOR LOCALIZATION AND THERAPY II. STUDY ON THE NEW PHOTOSENSITIZING AGENT PSD-007
- VernacularTitle:肿瘤光敏诊治药物的研究——Ⅱ、新光敏剂PSD-007的研究
- Author:
Deyu XU
- Publication Type:Journal Article
- From:
Academic Journal of Second Military Medical University
1982;0(01):-
- CountryChina
- Language:Chinese
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Abstract:
Here were reported the preparation and physicochemical properties of a new hema-toporphyrin photosensitizer PSD-007 and its selective uptake in tumor and the efficiency of experimental photolocalization and photoradiation therapy of Sarccma S180 bearing mice.The high photosensitizing PSD-007 with constant composition was prepared from hcmatoporphyrin photosensitizer PSD-001 by the removal of nearly 70% of its low PBT effect components.In comparison with US HPD, the amount of PSD-007 retained in tumor at the different intervals following iv injection was twice that of HPD showing excellent selective tumor PRT effect.In the tumor tissue of sarcoma S180 bearing mice which received an iv injection of 5-10 mg/kg body weight of PSD-007 appeared a bright orange fluorescene and thus it was clearly distinguished from the normal tissues around it at 24 and 48 hrs after injection on exposure to UV light and argon ion laser respectively. And when argon laser irradiation was applied for 20 min, it becomes ecchymosis, partial sclerosis, smoo-thening, and hollow around the center or partial slough after 24 hrs. This showed the reliable effect of experimental photolocalization and photoradiation therapy of tumors.The principal pharmacokinetic parameters of PSD-007 following iv injection to rabbits were also reported which provided a possible reference guide for the resonable administration of this drug in clinical practice.
