ON THE BIOCHEMICAL ACTION AND RADIORESISTANT ACTIVITY OF POLYSACCHARIDES EXTRACTED FROM RADIX BUPLEURI AND POLYPORUS UMBELLATE(PERS.)
- VernacularTitle:柴胡和猪苓多糖的生化作用及抗辐射损伤原理的研究
- Author:
Baozhang LU
;
Zhongchen WU
;
Jingrui SHAN
;
Yuanji XU
- Publication Type:Journal Article
- From:
Medical Journal of Chinese People's Liberation Army
1982;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Polysaccharides extracted from radix of Chinese DC and dried Polyporus umbellate (pers) as well as a well known mitogen,phytohemagglutinin(PHA),were studied.It has been revealed that both the poly-saccharides as well as PHA stimulate the rate of DNA synthesis characterized by their increasing the incorporation of 3H-TdR and accelerating the release of thymus cells. These effects disappeared after adrenalectomy.Corticosterone concentration was found to be increased in the plasma after the administration of the polysaccharides These phenomena suggested that the adrenal cortex was the mediator of their actions. When they were administered to animals before an irradiation of 800 rad, the survival rate was increased by 30-70% over that of the controls. The mechanism of the effects was discussed.
