EFFECT OF ANISODINE ON BRAIN MONOAMINE
- VernacularTitle:樟柳碱对脑组织单胺类神经介质含量的影响
- Author:
Peigen KUANG
;
Fulin DAI
;
Xinfu ZHOU
;
Bo XU
;
Yongcang LI
;
Fengying ZHANG
- Publication Type:Journal Article
- From:
Medical Journal of Chinese People's Liberation Army
1982;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
The effect of anisodine on brain monoamine was studied in 30 rats. The brain monoamine levels of caudate nucleus, hippocampus, diencephalon, brain stem and cerebral cortex were estimated by fluoro-metric method in drug-treated rats and saline-treated controls. Only the NE level of the brain stem was significantly increased in anisodine-treated animals 48 hours after injection. There were no significant differences in the dopamine values between anisodine-treated rats and saline-treated controls, while the 5HT and 5HIAA levels were significantly increased in anisodine-treated animals. The relation of brain monoamines to learning and memory is discussed. The increased 5HT and 5HIAA levels caused by anisodine may play a role in the impairment of memory.
