PREDICTABILITY STUDIES ON THE EFFICACY OF ANTICANCER DRUGS
- VernacularTitle:抗癌药物疗效预测的实验研究
- Author:
Yusen YAN
- Publication Type:Journal Article
- From:
Medical Journal of Chinese People's Liberation Army
1983;0(05):-
- CountryChina
- Language:Chinese
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Abstract:
An in vitro drug sensitivity assay was developed in this hospital. Human cancer cells from biopsy or surgery which were treated with different anticancer drugs were used and the incorporation efficiency of 2H-thymidine into DNA of cancer cells was compared with the control group.The experimental results demonstrate that mito-mycin C and fluorouracil are the most active drugs for the treatment of gastric cancer. Vincristin and Sarcandra glaber are less effective. As far as breast cancer is concerned the activated cyclophosphamide and fluorouracil are most effective, while mitomycin C and mustine hydrochloride are less effective. Bu-fonis venenum was shown to be inactive in gastric cancer and breast cancer.The method is simple and it can be used for the predictability studies in cancer clinics.
