TUMOUR CHEMOTHERAPY: SYNTHESIS OF SOME NEW TRIAZENES
- VernacularTitle:肿瘤化学治疗的研究 新的三氮烯类化合物的合成
- Author:
Jiqou YANG
- Publication Type:Journal Article
- From:
Academic Journal of Second Military Medical University
1982;0(01):-
- CountryChina
- Language:Chinese
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Abstract:
In the present paper, the synthesis of fourteen P, P'-bis(3,3-dialkyl-l-tria-zeno) -3, 4-diphenylhexane derivatives as potential antitumour agents were presented.These compounds were obtained by diazotizing respectively meso and race-mic P, P'-diamino-S, 4-diphenylhexane and then the corresponding diazonium salts were condensed with appropriate dialkylamines in an alkaline solution. The synthetic compounds have all been subjected to experimental antitumour tests, preliminary results showed that racemic P, P'-bis(3, 3-dimethyl-l-triazeno)-3, 4-diphenylhexane(designated as IX) inhibited prominently the growth of Leukemia L615, L7712 carcinoma of mice, inhibited moderately the growth of B16 melanoma and Lewis carcinoma of lung; meso P, P'-bis(3, 3-dimethyl-l-triazeno)-3, 4-diphenylhexane(designated as Dpossessed only slight inhibitory effect against Lewis carcinoma of lung.The other bis dialkyltriazenes are inactive under the same conditions.