STUDIES ON LABORATORY AND CLINICAL SIGNIFICANCES OF THE LIVER SPECIFIC MEMBRANE LIPOPROTEIN IN LIVER DISEASESrWITH PRELIMINARY ANALYSIS OF 80 CASES
- VernacularTitle:肝特异性膜脂蛋白的实验研究及其在肝病中临床意义探讨——附80例资料初步分析
- Author:
Yang YU
- Publication Type:Journal Article
- From:
Academic Journal of Second Military Medical University
1981;0(03):-
- CountryChina
- Language:Chinese
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Abstract:
The isolation, purification and identification of liver-specific membrane lipo-protein (LSP) is briefly presented. Human fetal liver was homogenized and submitted to 105,000 g for 1 hour. The supernatent was detected with presence of LSP. It was then fractioned by chromatography through Sephadex G-100 and Sephadex G-200. LSP revealed in the first peak.Nine rabbits of both sexes, weighing about 3 kg, were immunized with LSP to prepare antiserum. 80 sera of various liver disease patients were detected. Evidence of an immune response to the LSP was present in 18 of 23 cases (78.2%) of chronic active hepatitis. This observation suggests that the LSP may play an important role in the pathogenesis of liver injury.
