RESEARCH INTO THE ACTION AND MECHANISM OF LARGE DOSE OF ViT.C ON COLD TOLERANCE AND ADAPTATION IN GUINEA PIGS
- VernacularTitle:大剂量维生素C对机体耐寒性和心肌作用的研究
- Author:
Yin SU
;
Chengfa WANG
- Publication Type:Journal Article
- From:
Acta Nutrimenta Sinica
1956;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
117 guinea pigs were divided into groups, receiving 1mg, 5mg, 50mg and 100mg Vit C per os daily respectively in 2-4 weeks. There were conducted four experiments: (1) the effect of different vitamin C levels on the cold tolerance and adaptation in guinea pigs; (2) effect of large dose of vitemin C on sudden and long time exposure to cold: (3) the action of vitamin C, in large dose and short time in combination with hormones, on cold tolerance of guinea pigs; (4) effect of large dose of vitamin C on the myocardial enzyme activity, during the process of cold adaptation. Rectal temperature, body weight, weight and vitamin C contents of adrenal glands, the excretion of urinary 17-Ketostero'ids, activity of myocardial succinic dehydrogenase and cytochrom C oxidase were observed. The results revealed that large dose of Vitamin C per os might lessen the lowering of rectal temperature and body weight after exposure to cold; promote the activities of myocardial enzymes. Better results were obtained with combination of vitamin C with cortisones. It was noted that large dose of vitamin C apparently increased and accelerated the tolerance and adaptation of organisms to cold.
