STUDIES ON THE INTERRELATIONSHIP OF RIBOFLAVIN AND PROTEIN METABOLISMⅠ. EFFECT OF RIBOFLAVIN DEFICIENCY UPON THE REGENERATION OF TISSUE (LIVER, MUSCLE AND PLASMA) PROTEINS
- VernacularTitle:核黄素与蛋白质代谢的关系——Ⅰ.核黄素缺乏对于肝、肌肉和血浆中蛋白质再生作用的影响
- Author:
Chengfa WANG
- Publication Type:Journal Article
- From:
Acta Nutrimenta Sinica
1956;0(02):-
- CountryChina
- Language:Chinese
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Abstract:
Although the relation between vitamin deficiency and protein metabolism has been reported by earlier investigators, no study of the effect of riboflavic deficiency on the regeneration of tissue proteins has yet been made. This paper is a report of an investigation on the effect of riboflavin deficiency upon the regeneration of liver, muscle and total circulating plasma proteins in adult rats. The riboflavin store in the body of rats was first depleted by feeding riboflavin-free diet in the course of 36 days. Then moderately severe deficiency symptoms of both riboflavin and protein were induced during a period of 12 days by a riboflavin- and protein- free diet. After the deficiency of riboflavin and protein had been established, the depleted rats were then treated with complete and riboflavin-free diets for an appropriate period. The results are listed as following.1.The omission of riboflavin from normal complete diet of adult rats caused a regular reduction of weight and food consumption during the depletion period, the severity of which was markedly increased when protein was withdrawn from the riboflavin-free diet as well.2.The regeneration rate of liver and total circulating plasma proteins of both riboflavin and protein deficient rats decreased slightly when treated with riboflavin-free but proteinadequate ration. While the muscle protein was lost in greater amount instead of regenerated.The experimental work was made in former National Institute of Health Nanking.
