PHARMACOLOGICAL INVESTIGATION ON "FU-TZE" (A CHINESE HERBAL MEDICINE) IV. THE EFFECTS OF ACONITE ROOT ON BLOOD PRESSURE IN CATS, WITH SPECIAL RESPECT TO THE MECHANISM OF ITS ACTION
- VernacularTitle:中药附子的研究——Ⅳ、附子的血压效应及其机理分析
- Author:
Kemin GU
- Publication Type:Journal Article
- From:
Academic Journal of Second Military Medical University
1982;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
This paper deals with the effects of a boiled aqueous extract of the root of Aconitum carmichaeli Dibx. on blood pressure in cats. At lower dosage it only reduced the blood pressure, while in higher dosage it gave a triphasic response with an initially transient drop, followed by a prompt rise and a final reduction for considerable duration. Basing on the pharmacological analysis, it seems to be a reciprocally reacting between the pressor and depressor effects. The pressor effect was induced directly by acting on the ?-receptors of the vascular wall; while the depressor effect was concerned with the M-receptors,?2-recptors and some others, possibly central nervous system and ganglia also come into play. Considering the facts that when the N-receptors of ganglia being blocked the vasopressor responses were augmented rather than diminished, these findings were quite different from the data reported by others. It suggests that some unknown mode of action or substances in the preparation directly acting on the cardiovascular system might exist.
