The distribution of HLA-A,B,DRB1 alleles and haplotypes Guangzhou blood donors
- VernacularTitle:广州地区献血人群HLA-A、B、DRB1高分辨等位基因及单体型多态性的研究
- Author:
Haoqiang DING
;
Xin YE
;
Huaqin LIANG
;
Yangkai CHEN
- Publication Type:Journal Article
- Keywords:
HLA;
High-solution typing;
Haplotype;
Blood donors
- From:
Chinese Journal of Immunology
2000;0(09):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To analyze the polymorphism and haplotypes of HLA-A,B,DRB1 loci in Guangzhou blood donors.Methods:PCR-SSP methods were applied to determine HLA-A,B,DRB1 genotypes of 1 691 unrelated healthy individuals from Guangzhou,and the frenquencies of alleles and haplotypes were calculated with software of Pypop.Results:37 HLA-A alleles,76 HLA-B alleles and 43 HLA-DRB1 alleles were detected,and A02:07-B46:01-DRB109:01 and A33:03-B58:01-DRB103:01 were the most common haplotypes in Guangzhou blood donors.Conclusion:The distribution of alleles and haplotypes of Guangzhou blood donors are close to those of southern Chinese population and provide more genetic information in anthropology,transplantation and studies involoing disease association.
