Study on value of NMO-IgG in diagnosis of neuromyelitis optica
- VernacularTitle:视神经脊髓炎特异性自身抗体NMO-IgG的诊断价值研究
- Author:
Yang YANG
;
Dehui HUANG
;
Weiping WU
- Publication Type:Journal Article
- Keywords:
Neuromyelitis optica;
Autoantibody NMO-IgG;
Multiple sclerosis
- From:
Chinese Journal of Immunology
2000;0(09):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the value of NMO-IgG in diagnosis of neuromyelitis optica(NMO).Methods:A total of 120 patients with NMO,including high-risk NMO(HR-NMO),multiple sclerosis(MS),and other neurological diseases were enrolled in the study.The titres of serum NMO-IgG in all patients’ were detected by indirect immunofluorence.Results:The sensitivity and specificity of NMO-IgG were 67%,92% respectively in diagnosis of NMO.There were significantly differences in serum NOM-IgG posieivity among patients with NMO and MS who experienced severe optical neuritis,transverse myelitis,spinal-cord lesion beyond 3 segments as well as the patients with normal MRI scan in brain brain normal in MRI scan,serum and accompanied with other immunological disorders(P
