PHARMACOLOGICAL INVESTIGATION ON"FU-TZE" (A CHINESE HERBAL MEDICINE) V. THE EFFECTS OF ACONITE ROOT ON A PATHOLOGICAL MODEL TERMED "THE PULSE SCARCELY FELT
- VernacularTitle:中药附子的研究——Ⅴ、附子对“脉微欲绝”病理模型的影响
- Author:
Zhen ZUO
- Publication Type:Journal Article
- From:
Academic Journal of Second Military Medical University
1982;0(01):-
- CountryChina
- Language:Chinese
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Abstract:
Observations on blood pressure and myocardial contraction were taken on 20 cats under urethane anesthesia and artificial respiration. 3% sodium pentobarbital solution was injected intravenously into the cats until the blood pressure dropped to about 10 mm Hg, the heart beat nearly arrested and the pulsation scarcely felt, then, the boiled extract of aconite root equivalent to dried herb 100-400 mg/kg was injected intravenously, the response of the cats were striking, the blood pressure rose markedly, and the amplitude of myocardial contraction significantly enhanced. Same results were obtained when the experiments were repeated.By pharmacological analysis it is more likely that the pressor effect is due to the stimulation action on the ?-receptor of the vascular wall and the cardio-tonic effect is in connection with ?1-receptor of the myocardium.
