Effects of Xuefurong capsules on sexual function and nNOS expression in paraventricular nucleus in male castrated rats
- VernacularTitle:雪芙蓉胶囊对去势雄性大鼠性功能和下丘脑室旁核一氧化氮合酶表达的影响
- Author:
Jianmei CUI
;
Xiaoyang WANG
;
Hongyu LIU
;
Lei ZHANG
;
Xiaoxia SONG
- Publication Type:Journal Article
- Keywords:
Xuefurong capsules;
castrated rat;
sexual function;
paraventricular nucleus;
nitric oxide synthase
- From:
Journal of Xi'an Jiaotong University(Medical Sciences)
2004;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the effects of Xuefurong capsules,the traditional Chinese medicine for invigorating the kidney,on sexual function and expression of neuronal nitric oxide synthase(nNOS) in paraventricular nucleus(PVN) in adult castrated SD rats.Methods The male castrated rat model was made and three days after operation the liquid of Xuefurong capsules(5 mg/kg) was given by intragastric administration once a day for 28 days.The sexual function was observed and the nNOS expression in PVN was detected by using ABC immunohistochemical method.The number,area and gray degree of nNOS were counted and analyzed with semi-quantitative method.Results ①Compared with that in the castrated group,the serum testosterone level increased obviously in Xuefurong group(P0.05).Conclusion Xuefurong capsules can increase the level of testosterone,enhance the sexual function of castrated rats and nNOS expression in PVN.
