CYP2C9*3 and MSA2756G gene polymorphisms in patients with hyperlipemia in Ningxia Hui population
- VernacularTitle:宁夏回族高脂血症患者CYP2C9*3、MSA2756G基因多态性的研究
- Author:
Juyi LI
;
Jing JIN
;
Peng GAO
;
Juan DU
;
Jian WANG
- Publication Type:Journal Article
- Keywords:
hyperlipidemia;
CYP2C9;
methionine synthase;
polymorphism;
Ningxia Hui population
- From:
Journal of Xi'an Jiaotong University(Medical Sciences)
2004;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the distribution of CYP2C9*3 and methionine synthetase(MSA2756G) genes related to drug therapy in hyperlipidemia patients of Ningxia region as well as its relation with hyperlipidemia.Methods Genotype was determined by using amplication-created restriction sites(ACRS) and polymerase chain reaction-restriction fragment length polymorphism(PCR-RFLP) in hyperlipidemia patients.Results Among the 180 hyperlipidemia patients of Ningxia Hui population,the frequency of CYP2C9*3 alleles was 3.33% and mutation rate in men(3.05%) was significantly higher than that in women(0.28%)(P0.05).The frequency of MSA2756G(15.83%) alleles was significantly higher than that in healthy control group(10.25%)(P
