Expression of STAT3 and its relation with LMP1 expression in human nasopharyngeal carcinoma
- VernacularTitle:鼻咽癌组织中信号转导与转录活化因子3与潜伏膜蛋白1的表达及其关系
- Author:
Minhua WU
;
Xiaoyi CHEN
;
Dong CHEN
- Publication Type:Journal Article
- Keywords:
nasopharyngeal carcinoma(NPC);
signal transducer and activator of transcription 3(STAT3);
latent membrane protein 1(LMP1)
- From:
Journal of Xi'an Jiaotong University(Medical Sciences)
2004;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the expression and activation of signal transducer and activator of transcription 3(STAT3) in human nasopharyngeal carcinoma (NPC) tissues and its relation with the expression of latent membrane protein 1(LMP1) encoded by Epstein-Barr virus.Methods The expressions of LMP1,STAT3 and phosphated STAT3(p-STAT3) in 45 cases of NPC and 27 cases of chronic nasopharyngitis were studied by immunohistochemical method.Correlation between protein expressions was analyzed.Results The positive rates of LMP1,STAT3 and p-STAT3 in NPC were significantly higher than those in chronic nasopharyngitis(P0.05).Conclusion There are overexpression and abnormal activation of STAT3 protein in NPC tissues.LMP1 may play a role in the activation of STAT3.
