Expression and clinical significance of vascular endothelial growth factor and epidermal growth factor in non-small cell lung cancer
- VernacularTitle:VEGF及EGFR在非小细胞肺癌组织中的表达及临床意义
- Author:
Yiyi SONG
;
Aiqin GU
;
Baohui HAN
;
Shaojun ZHANG
- Publication Type:Journal Article
- Keywords:
vascular endothelial growth factor;
epidermal growth factor receptor;
non-small lung cancer
- From:
China Oncology
2006;0(07):-
- CountryChina
- Language:Chinese
-
Abstract:
Background and purpose:Both very important therapeutic targets of NSCLC,vascular endothelial growth factor (VEGF) and epidermal growth factor receptors (EGFR),are over expressed in non-small cell lung cancer (NSCLC).The aim of this study was to discuss the expression of VEGF and EGFR in NSCLC as well as its clinical significance.Methods:The expression of VEGF and EGFR was detected in 186 NSCLC samples using the immunohistochemical method.The expression of VEGF and VEGR in NSCLC patients with various pathological characteristics was observed and the correlation between them was analyzed.Results:The expression of VEGF in NSCLC was correlated with lymph node metastasis (P
