Shikonin inhibits the chemotaxis of monocytes in endometriosis via regulating RANTES expression
- VernacularTitle:紫草素通过调控RANTES抑制子宫内膜异位症单核细胞募集
- Author:
Dongping YUAN
;
Yingli SHI
;
Lin GU
;
Rong SHEN
;
Jie CHEN
- Publication Type:Journal Article
- Keywords:
Shikonin;
Endometriosis;
RANTES
- From:
Chinese Journal of Immunology
2001;0(07):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To evaluate the effect of shikonin on the expression of RANTES and chemotactic activity of monocyte in endometriosis.Methods:Established SCID endometriosis models and cultured U937 cells were treated by a series of concentration of shikonin.RANTES transcriptive expression was determined by Real-time PCR,and RANTES secretion was determined by ELISA.Furthermore,Chemotaxis assay in vitro was conducted to elucidate the effect of shikonin on chemotaxis of U937 cells by RANTES.Results:Shikonin improved the RANTES transcription of human endometrium transplanted to SCID mouse(P
