HEMODYNAMIC EFFECTS OF ANTICHOLINERGIC DRUGS ON ANESTHETIZED DOGS
- VernacularTitle:抗胆碱药对麻醉狗血流动力学的影响
- Author:
Keyao ZHENG
- Publication Type:Journal Article
- From:
Academic Journal of Second Military Medical University
1982;0(01):-
- CountryChina
- Language:Chinese
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Abstract:
The normal ranges of the hemodynamic changes including arterial blood pressure, heart rate, cardiac output and blood flows of common carotid artery, renal artery and femoral artery were observed in 12 anesthetized dogs for a period of three hours.The effects of three anticholinergic drugs (atropine sulfate, scopolamine hydrobromide and anisodamine hydrochloride) on hemodynamic changes were observed in those dogs. The dosages used were 2, 4, 8 and 16 mg/kg. After intravenous injections larger dosage of the above mentioned drugs, the mean arterial blood pressure was significantly depressed, heart rate decreased, cardiac output increased and renal blood flow reduced. The total peripheral resistance and that of common carotid artery and femoral artery were also reduced. The experimental results show that, among the three drugs, the hemodynamic effect of atropine is the strongest, anisodamine the next, and scopolamine the weakest.
