The study on HLA-A*02 allele frequency and its relationship with the susceptibility to lung cancer in Yunnan Xuanwei
- VernacularTitle:HLA-A*02等位基因与云南宣威肺癌相关性研究
- Author:
Ruizhu TANG
;
Yu LEI
;
Jimei LI
;
Ping HAO
- Publication Type:Journal Article
- Keywords:
Yunnan Xuanwei lung cancer;
HLA-A allele;
HLA-A*02 subtypes;
Gene frequency
- From:
Chinese Journal of Immunology
2001;0(07):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To study the frequency and distribution of HLA-A alleles and HLA-A*02 subtypes in the lung cancer patients in Yunnan Xuanwei area.This study aims at providing the significant genetic information for lung cancer research and treatment.Methods:Genomic DNA samples were collected from lung cancer patients and healthy donors residing in Yunnan Xuanwei area.HLA-A alleles and HlA-A*02 subtypes were typed by PCR-SSP assay.Case-control study was used to study the difference of frequency distribution between patients and normal controls.The polymorphisms of HLA-A*02 were also observed in cancer patients.Results:The positive rates of HLA-A*02 was significantly higher in cancer patients than in healthy controls (P=0.004,OR=2.432,95% CI=1.314-4.500),which were 68.75% and 47.50%,respectively.The gene frequency of HLA-A*02 was significantly higher in cancer patients than in healthy controls(P
