A comparative study of the kidney in two-kidney one-clip and spontaneous hypertension rats
- VernacularTitle:两肾一夹型与自发性高血压大鼠肾病变的比较
- Author:
Xin AN
;
Jianzhong ZHANG
;
Kan YANG
;
Fengying GUO
;
Li JING
- Publication Type:Journal Article
- Keywords:
hypertension;
glomerulus;
small artery;
afferent arteriole;
rat
- From:
Journal of Xi'an Jiaotong University(Medical Sciences)
1982;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To compare the pathological changes of the kidney in two-kidney one-clip hypertension and spontaneous hypertension rats so as to provide some experimental basis for clinical prevention and treatment of primary and secondary hypertension. Methods Conventional histopathology and elastic staining methods were used to observe the morphological changes of kidney tissues and renal arterioles from two-kidney one-clip (2K1C) and spontaneously hypertensive rats (SHR) of different weeks of age. Results The blood pressure of 2K1C rats after 4 weeks of operation reached (187?24)mmHg,which was significantly higher than that of controls (P
