MR Study of the Brain in Rats with Chronic Unpredicted Comprehensiveness Stress
- VernacularTitle:慢性应激导致大鼠颅脑损伤的磁共振研究
- Author:
Man WANG
;
Shoufu XIE
;
Kuihe JIN
- Publication Type:Journal Article
- Keywords:
Stress;
Hippocampus;
Apoptosis;
Magnetic resonance(MR)
- From:Chinese Journal of Clinical Psychology
2001;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To study the relationship between the damage of the central neuron and the brain structure and function of the rats with chronic stress.Methods: Male Wistar rats(n=30) weighting about 185-255g were divided into the test group(T,n=15) and the contral group(C,n=15) randomly.The rats in group T were exposed to various types of stresses every day for consecutive 21 days.The rats in group C did not receive any stress during 21 days.Every rat was weighed,open-field tested and measured for the brain by MR before the test and on the 22nd day.Also,on the 22nd day,the brains were removed and cut coronally.The apoptosis was detected by techniques of terminal deoxynucleotibyl transferase(TdT)-mediated dUTP nick end labling(TUNEL).Results: Weight and the result of Open-field test: compared with group C,group T showed less weight,increased stopping time in the center,decreasing rearing and grooming and increased defecation after 21-day stress(P
