EML4-ALK fusion oncogene and non-small cell lung cancer
- VernacularTitle:EML4-ALK融合基因与非小细胞肺癌
- Author:
Jiayan CHEN
;
Min FAN
- Publication Type:Journal Article
- Keywords:
non-small cell lung cancer;
EML4-ALK;
fusion oncogene
- From:
China Oncology
2000;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Non-small cell lung cancer(NSCLC) is one of the most life-threatening human malignancies due to its high morbidity and mortality rates.Molecular targeted therapy is promising in treating some patients with NSCLC.However,it is still challenging to select proper candidates.The EML4-ALK fusion oncogene represents a novel molecular target which appears mainly in lung adenocarcinoma,and appears to be a potential biomarker associated with resistance to EGFR tyrosine kinase inhibitors.This review was intended to outline current status of preclinical and clinical research of this molecule.
