The dynamic expression of Nrf2 and HO-1 in spinal cord tissues of experimental autoimmune encephalomyelitis of rats and the mechanism underlying neuroprotective effect of edaravone
- VernacularTitle:Nrf2和HO-1在实验性自身免疫性脑脊髓炎大鼠脊髓中的动态表达及依达拉奉保护机制的研究
- Author:
Qiaolian ZHANG
;
Li GUO
;
Yanfang HU
;
Zhen JIA
;
Li LI
- Publication Type:Journal Article
- Keywords:
Multiple sclerosis;
Experimental autoimmune encephalomyelitis;
Edaravone;
NF-E2-related factor2;
Heme oxygenase-1;
Oxidative stress
- From:
Chinese Journal of Immunology
1985;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To study the effect of edaravone on EAE rats and the underlying mechanism.Methods:Wistar rats were immunized with GPSCH,and randomly divided into control group,EAE group,dexamethasone group,low dose of edaravone group and high dose of edaravone group.The morbidity of disease and clinical signs were observed.The pathological changes of spinal cord tissue sections were observed under light microscopy after HE staining and trichrome staining.The expression of Nrf2 and HO-1 was observed by immunohistochemistry.Results:Morbidity of high dose of edaravone group (8.33%) and DXM group (0%) was significantly lower than in EAE group (58.3%) (P
