Influence of disease severity and antituberculosis treatment effectiveness on helper T-cells in peripheral blood from patients with pulmonary tuberculosis
- VernacularTitle:外周血辅助性T细胞亚群与肺结核严重性及疗效的关系
- Author:
Dexian LI
;
Tiantuo ZHANG
;
Shouyong TAN
;
Xianlan ZHANG
- Publication Type:Journal Article
- Keywords:
Pulmonary tuberculosis;
Radiology;
Helper T cell-1;
Helper T cell-2
- From:
Chinese Journal of Immunology
1985;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the influence of disease severity and effectiveness of antituberculosis treatment on helper T-cells in peripheral blood from patients with pulmonary tuberculosis.Methods:Th1 cells and Th2 cells of peripheral blood of 62 pulmonary TB patients and 30 controls were marked by intracellular cytokine(INF-? and IL-4 representative of Th1 and Th2 subsets respectively) and counted by Flow Cytometry.The levels of Th1 and Th2 cell count from patients with different disease severities radiologically before antituberculosis therapy were compared and their correlation with effectiveness of different antituberculosis treatment radiologically was analyzed either.Results:The baseline levels of Th1 cell count and Th2 cell count in pulmonary tuberculosis group before antituberculosis therapy were significantly lower than those in the control group(P0.05,t test).The levels of Th1 cell count in the stable group were still significantly lower than those in the control group(P
