The research on GSTT1 and GSTM1 gene polymorphisms of the patients with oligospermous infertility of Zhuang population in Guangxi area
- VernacularTitle:壮族人群少精不育患者精细胞GSTT1和GSTM1基因研究
- Author:
Wencheng CHEN
;
Xixiong KANG
;
Yesheng WEI
;
Yun PAN
;
Yali ZHOU
;
Guojun ZHANG
- Publication Type:Journal Article
- Keywords:
GSTM1;
GSTT1;
Oligozoospermia;
Infertility
- From:
Chinese Journal of Immunology
1985;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the association of the genes GSTM1 and GSTT1 with oligozoospermia infertility.Methods:PCR technique was used to analyze the GSTM1 and GSTT1 genes polymorphisms in 75 with oligospermia infertility and 36 healthy individuals of Zhuang population from Guangxi Baise area,and then the possibility function of GSTM1 and GSTT1 genes in human oligozoospermia were studied.Results:Analyses of the polymorphisms in GSTM1 and GSTT1 genes showed that GSTM1 defect or combined defects of both GSTM1 and GSTT1 was found more frequent in patients with infertile oligospermia than in the healthy control.Conclusion:GSTM1 and GSTT1 genes may have modulating effects on human spermatogenesis,whose mechanism needs further studies.
