The study of APRIL expression in non-small cell lung cancer
- VernacularTitle:APRIL在非小细胞肺癌中的表达研究
- Author:
Baolan SUN
;
Li ZHU
;
Xing WANG
;
Hongbing NI
;
Huimin WANG
- Publication Type:Journal Article
- Keywords:
A proliferation-inducing ligand;
RTQ-PCR;
NSCLC
- From:
Chinese Journal of Immunology
1985;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the expression of APRIL in NSCLC and to analyze the relationship between expression of APRIL and clinicalpathological characteristics of NSCLC.Methods:RTQ-PCR and Western blot were used to detect the expression of APRIL mRNA and protein in 68 pair of tumor tissues and corresponding adjacent normal tissues of NSCLC.50 Formalin-fixed,paraffin-embedded NSCLC samples were tested for APRIL protein location and expression by IHC,with results compared to the clinical and pathological parameters of NSCLC to determine significance.Results:The results showed that the expression level of APRIL mRNA and protein in tumor tissues was significantly higher than in normal tissues(both P
