Effect and mechanism of Ghrelin on the colonic motility of diabetic mice
- VernacularTitle:Ghrelin对糖尿病小鼠结肠动力的影响及机制
- Author:
Jun YAN
;
Wencai QIU
;
Weigang WANG
;
Zhigang WANG
- Publication Type:Journal Article
- Keywords:
Receptors,Ghrelin?Colonic motility?Diabetes complications?Mice
- From:
Chinese Journal of Current Advances in General Surgery
2004;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate colonic motility effect and mechanism of Ghrelin in diabetic mice.Methods:In vivo,the effects of Ghrelin(50,100,200 ?g/kg)on colonic transit of diabetic mice were measured by charcoal suspension pushing test.The effects of Atropine,N?-nitro-L-arginine methylester hydrochloride(L-NAME)and D-Lys3-GHRP-6(GHS-R antagonist)on the colonic transit of Ghrelin(200 ?g/kg)were also investigated.In vitro,the effects of Ghrelin on spontaneous contraction of proximal colonic circular muscle strips of diabetic mice were studied.Results:Ghrelin accelerated colonic transit of diabetic mice with significant dose-response relationship(P
