Expression and clinical implication of TGF-? and TGF-?1 in pancreatic carcinoma
- VernacularTitle:TGF-?和TGF-?1在胰腺癌组织中的表达及临床意义
- Author:
Qiang WANG
;
Bin ZHANG
;
Weiyu HU
;
Shun ZHANG
- Publication Type:Journal Article
- Keywords:
Pancreatic neoplasm?Tansforming growth factor?Immunohistochemistry
- From:
Chinese Journal of Current Advances in General Surgery
2004;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the expression of TGF-?,TGF-?1 in the tissues of pancreatic adenocarcinoma and normal pancreas,and study the changes and the relationships with the clinicopathological parameters of pancreatic adenocarcinomas.Methods:The expressions of the TGF-?,TGF-?1 were assayed in formalin-fixed paraffin embedded samples of 41 patients with pancreatic adenocarcinoma and 12 normal pancreatic tissues by means of SABC immunohistochemistry.The relationships between the expression and clinical parameters were analysied,such as ages,gender,tumor size,location,degree of differentiation and stage(UICC).Results:The positive rate of TGF-?,TGF-?1 were73.2%,63.4% respectively in pancreatic adenoeareinoma and were16.7 %,25% respectively in normal pancreatic tissues.Significant differences were found between the two groups(P
