Influences of 1,25-(OH)_2D_3 and salvia miltiorrhiza on hematopoiesis reconstruction and T cell subsets after allogeneic bone marrow transplantation in rats
- VernacularTitle:1,25-(OH)_2D_3及复方丹参对大鼠异基因骨髓移植后造血重建及T细胞亚群的影响
- Author:
Mei YAN
;
Bingzhao WEN
;
Yan CAO
;
Ming JIANG
- Publication Type:Journal Article
- Keywords:
T lymphocyte subset;
allogeneic bone marrow transplantation;
hematopoiesis reconstruction;
1,25-(OH)2D3;
salvia miltiorrhiza
- From:
Journal of Xi'an Jiaotong University(Medical Sciences)
1981;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the influences of 1,25-(OH)2D3 and salvia miltiorrhiza on hematopoiesis reconstruction and T cell subsets after allogeneic bone marrow transplantation in rats.Methods Donor rats were divided randomly into four groups,namely,Group A: aGVHD group;Group B: 1,25-(OH)2D3 group;Group C: salvia miltiorrhiza group;and Group D: two-drug combination group.We observed the survival time,peripheral blood cells,clinical manifestations of aGVHD and the changes of rat T cell subsets.Results Compared with those in aGVHD group,in every drug intervention group,the time for illness attack of aGVHD was delayed,aGVHD scoring was reduced and the average survival time was obviously prolonged(P
