Histopathological and hemodynamic changes of rats with liver cirrhosis
- VernacularTitle:肝硬化大鼠肝脏组织病理学及血流动力学变化
- Author:
Wei QIAO
;
Jianguo LU
;
Qing WANG
;
Pengchao LI
- Publication Type:Journal Article
- Keywords:
liver cirrhosis;
portal hypertension;
histopathology;
hemodynamics;
rat
- From:
Journal of Xi'an Jiaotong University(Medical Sciences)
1981;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the hemodynamic changes during the progression of portal hypertension(PHT) by establishing a model of liver cirrhosis in rats.Methods Totally 100 healthy male SD rats were assigned to 5 groups randomly(1 control group and 4 experimental groups with 20 rats in each group).Animal model of cirrhosis was established by subcutaneous injection of carbon tetrachloride(CCl4) and drinking alcohol.Rats in control group were given water and forage.The changes in the portal hemodynamics during the pathological process of liver tissues were observed after 2,4,7 and 10 weeks.Results During the formation of experimental cirrhosis,the hepatocytes of rats underwent 4 processes: degeneration,necrosis,fibrosis and pseudolobular proliferation.The hemodynamic changes were observed: the mean arterial pressure declined gradually after injection,but the portal venous pressure,the inferior vena cava pressure and the portal vascular resistance increased slowly.The portal venous flow reduced after ascending whereas the splanchnic vascular resistance increased after descending.Conclusion This method can establish a stable cirrhosis PHT model,which can be made in large quantities.During the progression of PHT,there are significant changes in portal vein hemodynamics and pathology,which can be used in related research on PHT.
