Preparation of chitosan coupled with folate by different connection ratio
- VernacularTitle:不同连接比例叶酸偶联壳聚糖的制备
- Author:
Ying ZHAO
;
Yan YANG
;
Shi LU
;
Hongling ZHANG
- Publication Type:Journal Article
- Keywords:
folate;
chitosan;
coupling;
gene therapy
- From:
Journal of Xi'an Jiaotong University(Medical Sciences)
1981;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To couple folate with chitosan and prepare folate-coupled chitosan by different connection ratio.Methods The folate-coupled chitosan was prepared by the reaction of the activated folate ester with the amine group on the chitosan.Then the folate-coupled chitosan was verified by infrared spectroscopy.The number of folates in each of the chitosans was measured by UV spectrophotometry.Results Infrared spectroscopy showed that the folate-coupled chitosan was prepared successfully,and the number of folates in each chitosan was approximately 3,10,20 and 30.Conclusion Coupling of folate with chitosan was successful,and folate-coupled chitosan by different connection ratio was successfully prepared.
