Effect of Hypertonic Seawater (Sinomarin(R)) on Mucociliary Clearance in Normal Subjects.
- Author:
Seung Hoon LEE
1
;
Jong Suk SONG
;
Sang Hag LEE
;
Soon Jae HWANG
;
Heung Man LEE
Author Information
1. Department of Otorhinolaryngology-Head and Neck Surgery, Korea University College of Medicine, Seoul, Korea. hmlee91@hotmail.com
- Publication Type:Original Article ; Randomized Controlled Trial
- Keywords:
Hypertonic seawater (Sinomarin (R));
Mucociliary clearance;
Saccharin clearance time (SCT)
- MeSH:
Mucociliary Clearance*;
Mucus;
Nasal Cavity;
Nasal Mucosa;
Saccharin;
Seawater*;
Therapeutic Irrigation
- From:Journal of Rhinology
2003;10(1, 2):19-22
- CountryRepublic of Korea
- Language:English
-
Abstract:
BACKGROUND AND OBJECTIVES: The effect of the hypertonic nasal douching solutions on mucociliary clearance was studied to ascertain the effect of hypertonic seawater. MATERIALS AND METHODS: Twenty-eight normal subjects were included in a randomized double -blind crossover trial. Hypertonic seawater (3%, Sinomarin(R)) was used as a hypertonic nasal douching solution. In order to determine the effect of hypertonic seawater on nasal mucosa, the mucociliary clearance was measured by the saccharin clearance time (SCT). RESULTS: The resultant SCT after administration of hypertonic seawater was significantly reduced compared with normal saline (0.9%)(p<0.05). CONCLUSION: This results showed that the hypertonic seawater improved mucociliary clearance time in the nasal cavity. The mechanism of this effect is probably brought about by changes in mucus viscoelastic properties.
