STUDIES ON PHOTOSENSITIVE DRUGS OF LOCALIZATION AND PHOTOTHERAPY OF MALIGNANT TUMORS I. STUDY ON THE PHQTOSENSITIZER HEMATOPORPHYRIN
- VernacularTitle:肿瘤光敏诊治药物的研究——Ⅰ.血卟啉光敏剂的研究
- Author:
Deyu XU
- Publication Type:Journal Article
- From:
Academic Journal of Second Military Medical University
1981;0(03):-
- CountryChina
- Language:Chinese
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Abstract:
An improved method for the preparation of photosensitizer hematophorphy-rin with hemin from anticoagulated fresh swine or ox blood was reported.The results of UV and IR absorption spectra, fluorescence spectra, and TLC analysis showed that the photosensitizer hematoporphyrin prepared in such a way was the same as reported.The aqueous sodium salt of photosensitizer hematoporphyrin is unstable.A new peak of emission fluorescence spectra (640 nm) appeared at the same excited wave length (395 nm) on exposure to sun light.This indicated the presence of photolytic product of the photosensitizer.The experiment of the kinetics of the drug showed that it is unstable both to light and heat.The fluorescence decay of the aqueous sodium salt of hematoporphyrin photosensitizer in accordance with the pattern of first-order reaction of kinetics.The results of biological test showed marked photo-inactivity of human carcinoma cell lines of different species in vitro,and the ability in detection and phototherapy of sarcoma 180 (solid) tumor in mice.
