Lack of Association between an Insertion/Deletion Polymorphism of the Angiotensin-Converting Enzyme Gene and Allergic Rhinitis in a Korean Population.
- Author:
Jae Hoon LEE
1
;
Tae Wook CHOI
;
Sung Weon YOON
;
Jeong Joong KIM
Author Information
1. Department of Otolaryngology, Wonkwang Institute of Medical Science, Wonkwang University School of Medicine, Iksan, Korea. coolnose@wmc.wonkwang.ac.kr
- Publication Type:Original Article
- Keywords:
Allergic rhinitis;
Angiotensin -converting enzyme gene;
Polymorphism;
Korean population
- MeSH:
Alleles;
Angiotensins;
Bradykinin;
Genotype;
Humans;
Neurokinin A;
Polymerase Chain Reaction;
Rhinitis*;
Substance P
- From:Journal of Rhinology
2003;10(1, 2):23-26
- CountryRepublic of Korea
- Language:English
-
Abstract:
BACKGROUND AND OBJECTIVES: Angiotensin -converting enzyme (ACE) inactivates bradykinin, substance P, and neurokinin A, which are thought to play important roles in the pathogenesis of inflammatory diseases. An insertion/deletion (I/D) poly - morphism in the ACE gene was reported to be associated with atopy in a Czech population. MATERIALS AND METHODS: Using the polymerase chain reaction, we investigated the frequencies of the genotypes and alleles of the ACE gene in 137 patients with allergic rhinitis and 498 healthy control subjects. RESULTS: There was no difference in the frequencies of the genotypes in the controls and patients with allergic rhinitis (p>0.05). The D allele was more frequent in patients with allergic rhinitis, but the difference was not statistically significant (p>0.05). CONCLUSION: Our results indicate that I/D polymorphism in the ACE gene is not related to susceptibility to allergic rhinitis in the Korean population.
