Research progresses on relationship between Wnt inhibitory factor-1 and tumor
- VernacularTitle:WIF-1与肿瘤关系的研究进展
- Author:
Lizhu JIANG
;
Hongyan CHEN
- Publication Type:Journal Article
- Keywords:
WIF-1;
tumor suppressor;
methylation;
Wnt;
tumor
- From:
China Oncology
1998;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
WIF-1 is an important antagonist in the Wnt/?-catenin pathway.As a tumor suppressor, WIF-1 is down-regulated in majority cancers but when it is correlated with WIF-1 promoter hypermethylation and treated with demethylation drug, its expression can be restored.Functional loss of WIF-1 due to promoter hypermethylation plays an important role in a tumor's pathogenesis, possibly mainly through aberrant canonical Wnt/?-catenin signal activation.The correlation of the expression of WIF-1 with clinicopathological features in different cancers is not identical.Detecting WIF-1 and promoter hypermethylation may offer help for early diagnosis, therapy and predicting prognoses.
