Pulmonary Toxicity of Three Typical Nanomaterials on Rats
- VernacularTitle:3种典型纳米材料对大鼠肺的毒性效应
- Author:
Huanliang LIU
;
Zhuge XI
;
Huashan ZHANG
- Publication Type:Journal Article
- Keywords:
Silver nanoparticles;
Zinc oxide nanoparticles;
Titanium dioxide nanoparticles;
Bronchoalveolar lavage fluid;
Oxidative damage;
Inflammatory factor;
Lipid peroxidation
- From:
Journal of Environment and Health
1992;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the toxic effect of lung and mechanism induced by silver nanoparticles(Nano-Ag),zinc oxide nanoparticles(Nano-ZnO)and titanium dioxide nanoparticles(Nano-TiO2) on rats.Methods Forty-two Wistar rats were divided into 7 groups randomly,including the control group,low(3.5 mg/kg) and high(17.5 mg/kg) dose groups of three nanomaterials.The rats were exposed by intratracheal instillation once two days for 5 weeks,and then killed by abdominal aorta bloodletting.The pathological examinations of rat lungs were performed,malondialdehyde(MDA),superoxide dismutase(SOD),reduced glutathione(GSH),nitrogen oxide(NO),interleukin-1(IL-1),interleukin-6(IL-6),tumor necrosis factor-?(TNF-?) and macrophage inflammatory protein(MIP-2) in bronchoalveolar lavage fluid(BALF) were detected.Results The results of histopathological analysis indicated that the fibrous tubercle,pulmonary alveoli destruction and the matrix inflammation of lung tissue appeared in the exposure groups.The activities of SOD in three kinds of nanoparticles groups(except for Nano-TiO2 subgroup) significantly decreased(P
