PRECLINICAL TOXICOLOGIC STUDIES ON NEW ANTIMALARIAL AGENT VIII. OBSERVATIONS OF THE PATHOLOGICAL CHANGES OF THE TOXIC EFFECT OF 5-P-FLUROPHENOXY PRIMAQUINE CITRATE(II)

VernacularTitle:新抗疟化合物的临床前毒性研究——Ⅷ、5-对氟苯氧基伯喹柠檬酸盐毒性试验的病理形态观察
Author: Pu ZHANG
Publication Type:Journal Article
From: Academic Journal of Second Military Medical University 1981;0(03):-
CountryChina
Language:Chinese
Abstract: Observations were made on the pathological changes of the heart muscles,livers and brains in dogs, monkeys and mice during the subacute toxic studies of 5-p-flurophenoxy primaquine citrate (MP-0090) which was compared with primaquine phosphate in same dosages.The results showed slight eosinophilic degeneration of heart muscles in some dogs and mice, focal ballon degeneration of liver cells in some dogs and fatty degeneration in one monkey.These changes were reversible and insignificant in clinic. Besides, no differences were found in pathologic changes between MP-0090 and primaquine phosphete.