THE EFFECT OF TRILOBINE HYDROCHLORIDE ON BLOOD PRESSURE IN CATS
- VernacularTitle:盐酸木防己碱对猫血压的影响
- Author:
Jianquan TAN
- Publication Type:Journal Article
- From:
Academic Journal of Second Military Medical University
1981;0(03):-
- CountryChina
- Language:Chinese
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Abstract:
Twenty-two casts of either sex were anesthesized with urethan, and their respiration, carotid arterial pressure (BP) and ECG were recorded.6 of the 22 cats were given trilobine iv of different doses of 1.25, 2.5,5.0, 10.0, 20.0mg/kg. It was found that all the dosage levels of trilobine produced a fall in blood pressure ranging from 30 to 60 mmHg. The extent of the hypo-tensive effect seems to be dose-dependent.The other 16 cats were divided into 3 groups and used to analyse the mechanism of the hypotensive action of trilobine.The first group (6 cats) was treated with the cholinergic M-receptor blokage-atropine, adrenergic ?-receptor blokage-propranol, ganglionic biokage-C6, and section of bilateral vagus nerve.The second group (5 cats) was treated with the adrenergic ?-receptor agonist-noradrenaline.The third group (5 cats) was treated with the histaminergic H1, H2-receptor blokage-diphenhydramine, cimetidine.The experimental results indicated that all of the above treatments had no influence on the hypotensive effect of trilobine, suggesting that the mechanism of hypotensive effect of trilobine may not relate to the cholinergic M, N receptor,the adrenergic ?, ? receptor, the histaminergic H1,H2 receptor and the vagus nerves.It is possible that a direct action on blood vessel may be involved.
